care (POC) testing, in addition to that for blood glucose, coagulation assays. © 2021 Walter de Gruyter GmbH, Berlin/Boston. We evaluated the analytical performance of the i-STAT Portable Clinical. The ACT was measured simultaneously with the other method. Creatinine measurements are used in the diagnosis and treatment of renal diseases, in monitoring renal dialysis, and as a calculation basis for measuring other urine analytes. Methods: We randomized 97 patients undergoing coronary artery bypass grafting or aortic valve replacement to either kaolin- or Celite-guided anticoagulation. i-STAT ACT is similar to traditional ACT tests except that the endpoint is indicated by a chemical measurement of the presence of thrombin instead of a mechanical measurement of a physical clot. Harmonized protocols and acceptability criteria are required to allow pooled data analysis and interpretation of different lipemic interference studies.Ĭentrifugation interference lipemia lipemic interference lipid removal. The i-STAT Creatinine test is used for the quantitative determination of creatinine (crea) in whole blood on the i-STAT handheld. With i-STAT ACT, healthcare professionals can measure the time required for complete activation of the coagulation cascade. Mixed results were reported for the remaining analytes.įor some analytes, high-speed centrifugation and/or lipid-clearing agents can be used in place of ultracentrifugation. Not only will you be able to strengthen your quality initiatives, but you’ll also be able to demonstrate compliance to. Lipid-clearing agents were uniformly effective for seven analytes: ALT, AST, total bilirubin, CK, creatinine (Jaffe method), lipase, and urea. These convenient solutions allow you to benchmark against peers, compare instruments, verify instrument calibration, assess staff competency, and morea wealth of tools in support of your continuous improvement. High-speed centrifugation was consistently effective for 13 analytes: albumin, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, creatine kinase (CK), creatinine (Jaffe method), gamma-glutamyl transferase (GGT), glucose (hexokinase-based method), lactate dehydrogenase (LDH), phosphate, potassium, and urea. 15 articles met the criteria for further analyses.Ī total of 66 analytes were investigated amongst the 15 studies, which showed highly heterogenous study designs. This systematic review summarizes existing literature on the effectiveness of lipid removal techniques in reducing interference in clinical chemistry tests.Ī PubMed search using terms relating to lipid removal from human samples for clinical chemistry tests produced 1,558 studies published between January 2010 and July 2021. There is little guidance available from manufacturers or professional bodies on processing lipemic samples to produce clinically acceptable results. Lipemia is the presence of abnormally high lipoprotein concentrations in serum or plasma samples that can interfere with laboratory testing.
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